Letrozole (Femara)

Letrozole is a medication that has gained popularity in recent years for its use in fertility treatments. Letrozole is an aromatase inhibitor, which means it blocks the production of estrogen in the body. This action can stimulate the release of follicle-stimulating hormone (FSH) from the pituitary gland, which can help to induce ovulation. In this blog post, we will explore the benefits, risks, and side effects of Letrozole use in fertility treatments, as well as its advantages over Clomid.

Benefits of Letrozole in Fertility Treatments

Letrozole has been shown to be effective in treating infertility in women with polycystic ovary syndrome (PCOS), a condition characterized by irregular periods, insulin resistance, and high levels of androgens (male hormones) in the body. It has been found to increase ovulation rates and improve pregnancy rates in women with PCOS. In addition, Letrozole can be used in women with unexplained infertility or in combination with intrauterine insemination (IUI) to increase the chances of pregnancy.

Letrozole vs Clomid

Letrozole is often compared to Clomid, another medication commonly used in fertility treatments. Both medications work by stimulating ovulation, but there are some important differences between the two. Letrozole has been shown to be more effective than Clomid in inducing ovulation and achieving pregnancy in women with PCOS. It also has fewer side effects than Clomid, such as a lower risk of multiple pregnancies, a lower risk of ovarian hyperstimulation syndrome (OHSS), and less impact on the cervical mucus.

Risks and Side Effects of Letrozole

Like any medication, Letrozole does carry some risks and side effects. The most common side effects of Letrozole are hot flashes, fatigue, and headaches. Some women may also experience nausea, dizziness, or changes in mood. Letrozole can also cause thinning of the endometrial lining, although rare, which can make it harder for a fertilized egg to implant in the uterus. However, this side effect is generally mild and can be counteracted with supplemental estrogen.

One of the most serious risks associated with Letrozole use is the potential for multiple pregnancies. Letrozole can stimulate the release of more than one egg, which can increase the risk of having twins, triplets, or more. Multiple pregnancies carry a higher risk of complications for both the mother and the babies, including premature birth, low birth weight, and gestational diabetes.


Letrozole is a medication that has shown promise in the treatment of infertility, particularly in women with PCOS. Compared to Clomid, Letrozole has fewer side effects and a lower risk of multiple pregnancies. However, like any medication, it does carry some risks and side effects that should be carefully considered before use. If you are struggling with infertility, it is important to speak with your healthcare provider about the best treatment options for you.